The Larry Sanders Show

The show stars Shandling as late night talk show host Larry Sanders, along with Jeffrey Tambor, and Rip Torn and features celebrities playing exaggerated, parodic versions of themselves. The show has its roots in Shandling's stand-up comedy background, his experience as a frequent guest host on The Tonight Show, and his earlier sitcom, It's Garry Shandling's Show. The program has had a marked and long-lasting influence on HBO as well as on television shows in the United States and United Kingdom, particularly shows like Curb Your Enthusiasm (which also aired on the same network), 30 Rock, and The Office. The supporting cast includes Janeane Garofalo, Wallace Langham, Penny Johnson, Linda Doucett, Scott Thompson, and Jeremy Piven.

The show received universal critical acclaim and is often regarded as an influential and landmark series. In 2010, it ranked 38 on TV Guide's 50 Greatest TV Shows of All Time, and was also included in Time magazine's 2007 list of the "100 Best TV Shows of All Time". The show won 24 major awards, including three Primetime Emmy Awards, five CableACE Awards, four American Comedy Awards, two British Comedy Awards, two Peabody Awards, a BAFTA Award and a Satellite Award. It also received 86 nominations, including 56 Primetime Emmy Awards nominations, five Directors Guild of America nominations, six Writers Guild of America nominations, six American Comedy Awards nominations, three Golden Globe nominations, three Satellite Awards nominations and a GLAAD Award nomination.